{"product_id":"tri-methyl-histone-h3-rabbit-monoclonal-antibody","title":"Tri-Methyl-Histone H3 rabbit monoclonal antibody","description":"\u003cp data-mce-fragment=\"1\"\u003e\u003cimg style=\"display: block; margin-left: auto; margin-right: auto;\" height=\"198\" width=\"258\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/1380\/2495\/files\/tri-methyl-histone-h3_Pancreatic-Adenocarcinoma-2-300x230.jpg?v=1663892696\" alt=\"\"\u003e\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003eH3K27me3 is a downstream target of the polycomb repressive complex 2 (PRC2); PRC2 contains evolutionarily conserved proteins essential for regulating gene expression. Gain- or loss-of-function mutations in EZH2, a component of PRC2, have been found in a variety of cancer types such as lymphoma, melanoma, and Myelodysplastic Lymphoma; gain-of-function mutations can result in H3K27Me hyperactivity and chromatin dysregulation. KDMA6A and B demethylases can act on H3K27Me, and loss-of-function mutations in these proteins have been found in solid and non-solid tumors including types of leukemia, lymphoma, melanoma, renal and bladder cancers, and in Medulloblastoma.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003eAs a gene transcription repressor, H3K27me3 has diverse roles in embryogenesis and neoplasia. Loss of H3K27me3 occurs in a significant subset of Malignant Peripheral Nerve Sheath tumors. Other neoplasms may show loss of H3K27me3 expression, such as Meningioma, Radiation Associated Unclassified Sarcoma, Radiation-Associated Angiosarcoma, Dedifferentiated Chondrosarcoma, Melanoma and Merkel Cell Carcinoma, amongst others. Some tumors may exhibit heterogeneous H3K27me3 expression (mosaic pattern).\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong\u003eIntended Use:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003eFor In Vitro Diagnostic Use. This antibody is intended for use in Immunohistochemical applications on formalin-fixed paraffin-embedded tissues (FFPE), frozen tissue sections, and cell preparations. Interpretation of results should be performed by a qualified medical professional.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\" style=\"text-align: center;\"\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/1380\/2495\/files\/PI3806_-_Tri-Methyl-Histone_H3_Lys27__H3K27Me3_RBT-H3K27Me3.pdf?v=1663892587\" target=\"_blank\" data-mce-href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/1380\/2495\/files\/PI3806_-_Tri-Methyl-Histone_H3_Lys27__H3K27Me3_RBT-H3K27Me3.pdf?v=1663892587\"\u003eProduct PDF \u003c\/a\u003e\u003c\/p\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"text-align: center;\"\u003e \u003cstrong data-mce-fragment=\"1\"\u003eAntibody Type:\u003c\/strong\u003e\n\u003c\/td\u003e\n\u003ctd style=\"text-align: center;\"\u003e\u003cspan\u003eRabbit Monoclonal\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd style=\"text-align: center;\"\u003e\u003cstrong\u003eClone:\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"text-align: center;\"\u003e\u003cspan\u003eRBT-H3K27Me3\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"text-align: center;\"\u003e\u003c\/td\u003e\n\u003ctd style=\"text-align: center;\"\u003e\u003cspan\u003e\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd style=\"text-align: center;\"\u003e\u003cstrong\u003e\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"text-align: center;\"\u003e\u003cspan\u003e\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"text-align: center;\"\u003e\u003cstrong\u003eIsotype:\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"text-align: center;\"\u003e\u003cspan\u003eIgG\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd style=\"text-align: center;\"\u003e\u003cstrong\u003eReactivity:\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"text-align: center;\"\u003e\n\u003cp\u003e\u003cspan\u003eParaffin, Frozen\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"text-align: center;\"\u003e\u003cstrong\u003e\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"text-align: center;\"\u003e\u003cspan\u003e\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd style=\"text-align: center;\"\u003e\u003cstrong\u003e\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"text-align: center;\"\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"text-align: center;\"\u003e\u003cstrong\u003eLocalisation:\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"text-align: center;\"\u003e\u003cspan\u003eNuclear\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd style=\"text-align: center;\"\u003e\u003cstrong\u003eControl:\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"text-align: center;\"\u003e\u003cspan\u003eNormal and most tumor tissues contains intact nuclear H3K27me3 expression\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ctable border=\"0\" width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"text-align: center;\"\u003e\u003cstrong\u003eCatalog No.\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"text-align: center;\"\u003e\u003cstrong\u003eAntibody Type\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"text-align: center;\"\u003e\u003cstrong\u003eDilution\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"text-align: center;\"\u003e\u003cstrong\u003eVolume\/QTY\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"text-align: center;\"\u003eBSB-3806-3\u003c\/td\u003e\n\u003ctd style=\"text-align: center;\"\u003ePrediluted\u003c\/td\u003e\n\u003ctd style=\"text-align: center;\"\u003eReady-To-Use\u003c\/td\u003e\n\u003ctd style=\"text-align: center;\"\u003e3.0 ml\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"text-align: center;\"\u003eBSB-3806-7\u003c\/td\u003e\n\u003ctd style=\"text-align: center;\"\u003ePrediluted\u003c\/td\u003e\n\u003ctd style=\"text-align: center;\"\u003eReady-To-Use\u003c\/td\u003e\n\u003ctd style=\"text-align: center;\"\u003e7.0 ml\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"text-align: center;\"\u003eBSB-3806-15\u003c\/td\u003e\n\u003ctd style=\"text-align: center;\"\u003ePrediluted\u003c\/td\u003e\n\u003ctd style=\"text-align: center;\"\u003eReady-To-Use\u003c\/td\u003e\n\u003ctd style=\"text-align: center;\"\u003e15.0 ml\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"text-align: center;\"\u003eBSB-3806-01\u003c\/td\u003e\n\u003ctd style=\"text-align: center;\"\u003eConcentrated\u003c\/td\u003e\n\u003ctd style=\"text-align: center;\"\u003e1:50-1:200\u003c\/td\u003e\n\u003ctd style=\"text-align: center;\"\u003e0.1 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center;\"\u003e5\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e","brand":"Bio SB","offers":[{"title":"Default Title","offer_id":42010393051329,"sku":"BSB-3806","price":0.0,"currency_code":"AUD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1380\/2495\/products\/biosb_black-240-300-v3.png?v=1663892205","url":"https:\/\/www.diagnostictechnology.com.au\/products\/tri-methyl-histone-h3-rabbit-monoclonal-antibody","provider":"Diagnostic Technology","version":"1.0","type":"link"}