CD117 c-Kit PolyDetector HRP/DAB

The CD117/c-kit PolyDetector HRP/DAB Detection System is a non-biotin, 2-step polymeric detection system that allows for the Immunohistochemical detection of CD117 expression in normal and neoplastic formalin-fixed paraffin-embedded tissues. The CD117/c-kit PolyDetector HRP/DAB Detection System has been developed using a proprietary tandem hyperlabelling technology used to directly label immunoglobulins with enzymes. This ensures consistent and reproducible immunostaining for CD117. CD117 is a tyrosine kinase receptor for stem cell factor (SCF), also known as “steel factor” or “c-kit ligand”. C-kit is a polypeptide that activates bone marrow precursors of a number of blood cells, but its receptor is also present on other cells. C-kit mutations in the interstitial cells of Cajal in the digestive tract are probably the key to gastrointestinal stromal tumors (GISTs). CD117 is found on interstitial cells of Cajal, germ cells, bone marrow stem cells, melanocytes, breast epithelium and mast cells. This receptor is found on a wide variety of tumor cells (Follicular and Papillary carcinoma of Thyroid, Adenocarcinomas from endometrium, lung, ovary, pancreas, breast; malignant melanoma, endodermal sinus tumor, small cell carcinoma) but has been particularly useful in differentiating Gastrointestinal Stromal Tumors (GIST) from Kaposi’s sarcoma and tumors of smooth muscle origin. 

Available options include 70, 150 and 500 tests.

For Research Use Only. 

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