MSH6 - Mouse monoclonal 44

MSH6 is a gene commonly associated with Hereditary Non-Polyposis Colorectal Cancer (HNPCC). HNPCC is an autosomal, dominantly inherited disease associated with marked increase in cancer susceptibility. It is characterized by a familial predisposition to early onset Colorectal Carcinoma and extra-colonic cancers of the gastrointestinal, urological and female reproductive tracts. HNPCC is reported to be the most common form of inherited Colorectal Cancer in the western world. MSH6 is a mismatch repair gene which is deficient in a high proportion of patients with microsatellite instability (MSI-H). The anti-MSH6 antibody is useful in screening patients and families for HNPCC. Colon cancers that are microsatellite-unstable have a better prognosis than their microsatellite-stable counterparts.

Available options include prediluted (3ml, 7 ml, 15ml), concentrate (0.1 ml, 0.5ml, 1ml) and 5+ control slides.

For Research Use Only.