IGH-BCL2 Fusion/Translocation FISH Probe Kit - 10 tests

IGH-BCL2 Fusion/Translocation FISH Probe Kit - 10 tests


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The IGH-BCL2 FISH probe set is designed to detect rearrangements involving regions of the human IGH locus, located on chromosome band 14q32.33, and of the human BCL2 gene on 18q21.33. The kit contains two differentially labeled Locus Specific Probe (LSP) pairs. One set of probes covers the 5’ (start) portion of the BCL2 gene and some upstream untranslated genomic sequence as well as sequences downstream of the 3’ (end) part of the gene. The two probes are flanking sequences on both sides and inside the BCL2 gene where breakpoint clusters and individual breakpoints have been found.

The second probe pair spans the immunoglobulin heavy chain gene locus (IGH@) and consists of a portion matching the 5’ (start) region encoding variable gene segments (IGHV), and a part that covers the 3’ (end) and downstream sequences. This probe pair is flanking an area of the IGH gene comprising constant gene segments (IGHC) as well as the delta segment (IGHD), joining region (IGHJ) and epsilon domain (IGHE). Almost all known breakpoints in IGH@ have been mapped to this region.

For Research Use Only.