LSP DSCR8 FISH Probe

The DSCR8 FISH Probe is designed to detect the human DSCR8 gene located on chromosome band 21q22.2. DSCR8 is also known as C21orf65,CT25.1a, CT25.1b, MMA-1, MMA-1a, MMA-1b, MMA1 or MTAG2.

The DSCR8 FISH probe is labeled with CytoOrange. CytoOrange is a fluorophore with an excitation peak at 551nm and emission peak at 575nm, giving it an orange fluorescent signal with the appropriate filters.

The DSCR8 FISH probe hybridizes to chromosome 21 in both metaphase and interphase cells. After hybridizing with normal human peripheral blood lymphocyte samples, two distinct orange fluorescent spots are observed in the interphase nuclei, each spot corresponding to the 21q22.2 region on the chromosome 21.  In metaphase cells, a “doublet” or “split signal” may appear on chromosomal region 21q22.2.  Each signal within the doublet represents one of the two sister chromatids present in the replicated chromosome 21.

For Research Use Only.