CytoTest LSP IPO11 FISH ProbeCT-LSP030
The IPO11 FISH Probe is designed to detect the human IPO11 gene located on chromosome band 5q12.1. IPO11 is also known as RanBP11.
The IPO11 FISH probe is labeled with CytoOrange. CytoOrange is a fluorophore with an excitation peak at 551nm and emission peak at 575nm, giving it an orange fluorescent signal with the appropriate filters.
The IPO11 FISH probe hybridizes to chromosome 5 in both metaphase and interphase cells. After hybridizing with normal human peripheral blood lymphocyte samples, two distinct orange fluorescent spots are observed in the interphase nuclei, each spot corresponding to the 5q12.1 region on the chromosome 5. In metaphase cells, a “doublet” or “split signal” may appear on chromosomal region 5q12.1. Each signal within the doublet represents one of the two sister chromatids present in the replicated chromosome 5.
For Research Use Only.