Kreatech™ ERBB2 (17q12) / SE 17 FISH probe

The proto-oncogene ERBB2 (also known as HER-2/neu) resides on chromosome 17q and encodes a trans-membrane tyrosine kinase growth factor receptor. Amplification of the ERBB2 gene, erbB-2 protein, is found in 20-30% of breast cancers and is also found to be amplified in prostate carcinoma, gastric cancer and uterus cancer. ERBB2 has been shown to predict response to specific breast cancer chemotherapeutic regimens, especially when combined with the humanized monoclonal antibody (MAb) Herceptin.

Intended use: The ERBB2 (17q12) specific FISH probe is optimized to detect copy numbers of the ERBB2 (Her2/neu) gene region at region 17q12. The Satellite Enumeration (SE) 17 FISH probe is included to facilitate chromosome identification

Kreatech probes are direct-labeled DNA probes provided in a ready-to-use format. Apply 10 ul of probe to a sample area of approximately 22 x 22 mm

Product SKUs:

• 10 tests: KBI-10701
• 50 tests: KBI-14701

ASP are developed for Research Use Only (RUO) and are not meant to be used for medical purposes or as a diagnostics tool. Arm Specific Probes are supplied in a ready-to-use format, and are available in two colours of choice: green and red. 

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