CD45RO - Mouse monoclonal 4KB5

The CD45 family consists of multiple members that are all products of a single complex gene. Three isoforms of CD45 exist: on B-lymphocytes, where the protein is called B220 (its molecular mass is 220 kDA); on naive T-lymphocytes, where it is called CD45 RA, and on activated and memory T-lymphocytes, where it is called CD45 RO. CD45RO is a single-chain, transmembraneous glycoprotein which represents the low molecular weight isoform of the Leukocyte Common Antigen (LCA). It is expressed on most thymocytes, about 45% of peripheral blood T-cells, virtually all T-cells in skin reactive infiltrates, and the majority of T-cell malignancies. It is also found on a subset of B-cells and on exceptional B-cell Lymphomas. CD45RO (T-Cell, Pan) antibody reacts with thymocytes and activated T-cells, but only on a subpopulation of resting T-cells. This antibody shows no reactivity with B-cells, making it a good marker for T-cell tumors to be phenotyped. In addition, granulocytes and monocytes are also labeled with this antibody. T-Cell, Pan has been designated as CD45RO at The International Leukocyte Typing Workshop.

Available options include prediluted (3ml, 7 ml, 15ml), concentrate (0.1 ml, 0.5ml, 1ml) and 5+ control slides.

For Research Use Only.