CDK2 RMab Rabbit RBT-CDK2BSB 2636-BSB 2642
CDK2 (also known as Cyclin-dependent kinase 2 or cell division protein kinase 2) is a 33 kDa enzyme that in humans is encoded by the CDK2 gene on Chromosome 12. CDK2 is a catalytic subunit of the cyclin-dependent kinase complex, whose activity is restricted to the G1-S phase of the cell cycle, and is essential for the cellular G1/S transition.Studies indicate that over expression of CDK2 may cause the abnormal regulation of cell-cycle, which would could directly contribute to hyper-proliferation of cancerous cells. HOX genes, which play a key role in cell differentiation and morphogenisis, are regulated by CDK2. Studies have shown that HOXA7 promoted cell proliferation (mediated by cyclin E1/CDK2) is evident in cases of Hepatocellular carcinoma, indicating that CDK2 may prove to be a useful marker in such cases.
Available options include prediluted (3ml, 7 ml, 15ml), concentrate (0.1 ml, 0.5ml, 1ml) and 5+ control slides.
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