Cytokeratin 5 & 14 & p63 RMab EP24/EP61/EP174

Cytokeratin 5 is a type II cytokeratin found in squamous cell epithelium, myoepithelial cells of the breast and the basal cells of the prostate. Cytokeratin 14 is a Type I polypeptide found in basal cells of squamous epithelia, some glandular epithelia, myoepithelium, and mesothelial cells. Together, they form the cytoskeleton of epithelial cells. p63 and p73 proteins can induce p53-responsive genes and elicit programmed cell death. p73 and p63 are more important during development and differentiation. In particular, p63 appears to be primarily implicated in epithelial development. Anti-CK5, along with Anti-CK14, has found application in identifying the basaloid phenotype of breast carcinoma, a tumor with poor prognosis. p63 labels the nuclei of myoepithelial cells in the prostate gland as well as breast tissue, making it useful in differentiating benign vs. malignant prostate lesions and breast lesions.

Available options include prediluted (3ml, 7 ml, 15ml), concentrate (0.1 ml, 0.5ml, 1ml) and 5+ control slides.

For Research Use Only.