Cytokeratin Cocktail, Mouse monoclonal AE1 & AE3

Cytokeratins are intermediate-filament keratins found in the intracytoplasmic cytoskeleton of epithelial tissue. There are two types of cytokeratins: the low-weight, acidic Type I cytokeratins and the high-weight, basic or neutral Type II cytokeratins. Cytokeratins are usually found in pairs comprising a Type I cytokeratin and a Type II cytokeratin. Expression of these cytokeratins is frequently organ or tissue-specific. Cytokeratin cocktail AE1/AE3 is well suited to distinguish Epithelial Carcinoma from Non-epithelial malignan-cies and is used to aid Epithelial Tumor classification. This antibody has been used to characterize the source of various neoplasms and to study the distribution of keratin-containing cells in epithelia during normal development and during the development of epithelial neoplasms. This antibody stains cytokeratins present in normal and abnormal human tissues. This antibody has shown high sensitivity and specificity in recogniz-ing epithelial cells of neoplastic origin.

Available options include prediluted (3ml, 7 ml, 15ml), concentrate (0.1 ml, 0.5ml, 1ml) and 5+ control slides.

For Research Use Only.