Factor XIIIa RMab EP3372

Factor XIII or fibrin stabilizing factor is an enzyme of the blood coagulation system that crosslinks fibrin. When thrombin has converted fibrinogen to fibrin, the latter forms a proteinaceous network in which every E-unit is crosslinked to only one D-unit. Factor XIII is activated by thrombin into Factor XIIIa; its activation into Factor XIIIa requires calcium as a cofactor. Factor XIIIa has been identified in platelets, megakaryocytes, and fibroblast-like mesenchymal or histiocytic cells present in the placenta, uterus, and prostate; it is also present in monocytes, macrophages and dermal dendritic cells. Anti-Factor XIIIa has been found to be useful in differentiating between Dermatofibroma (90% (+)), Dermatofibrosarcoma Protuberans (25%(+)) and Desmoplastic Malignant Melanoma (0%(+)). Factor XIIIa positivity is also seen in Capillary Hemagioblastoma (100%(+)), Hemangioendothelioma (100%(+)), Hemangiopericytoma (100%(+)), Xanthogranuloma (100%(+)), Xanthoma (100(+)), Hepatocellular Carcinoma (93%(+)), Glomus Tumor (80%(+)), and Meningioma 80%(+)).

Available options include prediluted (3ml, 7 ml, 15ml), concentrate (0.1 ml, 0.5ml, 1ml) and 5+ control slides.

For Research Use Only.