Histone H3 Phospho RMab EP233BSB 2524-BSB 2530
Phosphohistone-H3 is one of the five main histone proteins involved in the structure of chromatin in eukaryotic cells. Featuring a main globular domain and a long N-terminal tail, H3 is involved with the structure of the nucelosomes of the “beads on a string” structure. In mammalian cells, phosphohistone H3 is negligible during interphase but reaches a maximum for chromatin condensation during mitosis.
Phosphohistone-H3 can serve as a mitotic marker to separate mitotic figures fromapoptotic bodies and karyorrhectic debris, which may be a very useful tool in diagnosis of tumor grades, especially in CNS, skin, Gyn., soft tissue, and GIST.
For Research use Only.
Available options include prediluted (3ml, 7 ml, 15ml), concentrate (0.1 ml, 0.5ml, 1ml) and 5+ control slides.