LI-Cadherin RMab EP86BSB 6849-6855
LI-Cadherin, also known as Cadherin-17, is part of the cadherin superfamily and is a calcium-dependent, membrane-associated glycoprotein. Cadherins are responsible for mediating cell-cell adhesion and are important for the structural integrity of epithelia. LI-Cadherin consists of an extracellular region containing 7 cadherin domains, and a transmembrane region but lacking the conserved cytoplasmic domain. It is a component of the gastrointestinal tract and pancreatic ducts, acting as an intestinal proton-dependent peptide transporter in the first step in oral absorption of many medically important peptide-based drugs. It may play a role in the morphological organization of liver and intestine. In normal tissues, the LI-Cadherin antibody labels epithelial cells in the gastrointestinal tract and pancreatic duct, but not in kidney, liver and other tissues. In tumors, LI-Cadherin is expressed on adenocarcinoma of the digestive system, including liver cancer. It is a sensitve marker for the identification of gastric intestinal metaplasia and well differentiated adenocarcinomas.
Available options include prediluted (3ml, 7 ml, 15ml), concentrate (0.1 ml, 0.5ml, 1ml) and 5+ control slides.
For Research Use Only.