PU.1 RMab P18BSB 2154-BSB 2160
PU.1 is a member of the Ets family of transcription factors and is required for the development of multiple hematopoietic lineages. It plays a pivotal role in normal myeloid differentiation and regulates the expression of immunoglobulin and other genes that are important for B-cell development. It is expressed in the myeloid lineage and in immature as well as mature B lymphocytes, with the exception of plasma cells. PU.1 is expressed in germinal center B-cells and mantle B-cells. The antibody is positive in various lymphomas including B-Chronic Lymphocytic Leukemia, Mantle Cell Lymphoma, Follicular Lymphoma, Marginal Zone Lymphoma, Burkitt Lymphoma, Diffuse Large Cell Lymphoma, Diffuse Large B-cell Lymphoma, T-cell rich B-cell Lymphoma, Nodular Lymphocyte Predominant Hodgkin Lymphoma. It has been demonstrated that a high level of expression of GC antigens (including PU.1) has a positive association with longer overall survival and progression free survival in the case of Follicular Lymphoma.
Available options include prediluted (3ml, 7 ml, 15ml), concentrate (0.1 ml, 0.5ml, 1ml) and 5+ control slides.
For Research Use Only.