Bio SB Retinoblastoma (Rb) - Mouse monoclonal SPM353
Bio SB

Bio SB Retinoblastoma (Rb) - Mouse monoclonal SPM353

BSB 6127-BSB 6133

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The retinoblastoma protein (Rb) is a tumor-suppressor protein that is dysfunctional in many types of cancer. One highly studied function of Rb is to prevent excessive cell growth by inhibiting cell-cycle progression until a cell is ready to divide. Rb prevents the cell from replicating damaged DNA by preventing its progression along the cell cycle through G1 into S. Should an oncogenic protein (such as that produced by cells infected with high-risk types of human papillomaviruses, SV40 or Adenoviruses) bind and inactivate Rb, this can lead to cancer. Rb protein may act by regulating transcription; loss of its function leads to uncontrolled cell growth. Aberrations in the Rb gene have been implicated in cancers of breast, colon, prostate, kidney, nasopharynx, and Leukemia.

Available options include prediluted (3ml, 7 ml, 15ml), concentrate (0.1 ml, 0.5ml, 1ml) and 5+ control slides.

For Research Use Only.