CytoTest CCP13, 18, 21, X, Y FISH Probe Kit - 10 testsCT-PAC404
This CytoTest FISH probe set is designed to simultaneously determine the copy number of human chromosomes 13, 18, 21, X and Y, and to detect copy number aberrations in these chromosomes, in metaphase and interphase blood and tissue cells. The panel contains five different probes:
CCP18 is derived from chromosome 18 specific centromeric (18p11.1-q11.1) alpha satellite DNA (D18Z1).
CCPX is derived from X-chromosome specific alpha satellite DNA (Xp11.1-q11.1, DXZ1).
CCPY is derived from Y chromosome specific centromeric (Yp11.1-q11.1) alpha satellite DNA (DYZ3).
Note: CCPY probe derived from chromosome Y long arm satellite DNA (DYZ1) can also be provided if preferred.
CCP13 is a probe spanning the RB1 gene on 13q14 and adjacent sequences.
CCP21 is a probe covering the DSCR8 gene locus located on chromosome band 21q22.2.
The probe set is optimized to aid in the detection of copy number aberrations involving the five chromosomes. Trisomies of chromosomes 13, 18 and 21 as well as sex chromosome aneuploidies are the by far most common prenatal chromosomal aberrations. While the panel can also reveal other copy number defects including mono-, tetra- and polyploidies and other anomalies, a diverse range of specific abnormalities may not be detected by this panel such as localized inversions or balanced intrachromosomal translocations, centromeric polymorphisms, some microdeletions or microduplications, and other defect types.
For the detailed analysis of complex structural rearrangements, additional probes must be used, in addition to routine chromosome analysis and anatomical, biochemical and clinical information.
For Research Use Only.