LSP DCC FISH Probe

The DCC FISH Probe is designed to detect the human DCC gene located on chromosome band 18q21.2. DCC is also known as CRC18, CRCR1,MRMV1, IGDCC1 or NTN1R1.

The DCC FISH probe is labeled with CytoOrange. CytoOrange is a fluorophore with an excitation peak at 551nm and emission peak at 575nm, giving it an orange fluorescent signal with the appropriate filters.

The DCC FISH probe hybridizes to chromosome 18 in both metaphase and interphase cells. After hybridizing with normal human peripheral blood lymphocyte samples, two distinct orange fluorescent spots are observed in the interphase nuclei, each spot corresponding to the 18q21.2 region on the chromosome 18.  In metaphase cells, a “doublet” or “split signal” may appear on chromosomal region 18q21.2.  Each signal within the doublet represents one of the two sister chromatids present in the replicated chromosome 18.

For Research Use Only.