LSP ERBB4 FISH Probe

The ERBB4 FISH Probe is designed to detect the human ERBB4 gene located on chromosome band 2q34. ERBB4 is also known as HER4, ALS19 or p180erbB4.

The ERBB4 FISH probe is labeled with CytoOrange. CytoOrange is a fluorophore with an excitation peak at 551nm and emission peak at 575nm, giving it an orange fluorescent signal with the appropriate filters.

The ERBB4 FISH probe hybridizes to chromosome 2 in both metaphase and interphase cells. After hybridizing with normal human peripheral blood lymphocyte samples, two distinct orange fluorescent spots are observed in the interphase nuclei, each spot corresponding to the 2q34 region on the chromosome 2.  In metaphase cells, a “doublet” or “split signal” may appear on chromosomal region 2q34.  Each signal within the doublet represents one of the two sister chromatids present in the replicated chromosome 2.

For Research Use Only.